On Monday, October 6, 2025, the Karolinska Institute in Stockholm announced the winners of the Nobel Prize in Physiology or Medicine. This year’s laureates are Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi, recognized for their discoveries on peripheral immune tolerance – the mechanism by which the immune system identifies and protects the body’s own cells.
“Their work is fundamental to understanding how the immune system maintains balance and protects the body from attacks on its own cells,” said Olle Kämpe, Chair of the Nobel Committee.
Regulatory T Cells: Guardians of the Immune System
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